Abstract
Kalingathi Kadugu (KK) is a herbomineral Siddha formulation with its reference from the
classical Siddha text “Agathiyar vallathi 600”. Among the nine indications, Karupai
Kaluthuputru (Cervical cancer) has been specially mentioned in the text. Cervical Carcinoma,
the fourth most common cancerous disease diagnosed in women worldwide, is caused by
several factors such as human papillomavirus (HPV) etc. Compared to other treatment
methods, chemotherapy is the principal and most feasible method. The higher dosage
accompanies many post-treatment clinical consequences along with side effects. Nowadays
discovering molecules from classical traditional systems of medicine such as Siddha become
imperative as the system has many promising formulations like kalingathi kadugu for cancer
therapy.
The study intends to analyze the presence of the active compounds within the formulation KK
obtained from the classical Siddha literature “Agathiyar vallathi 600”.
KK was prepared from the Classical Siddha literature “Agathiyar vallathi 600” as per SOP.
The raw drugs were authenticated by the Chief consultant of Walter Siddha Research Centre,
Tirunelveli and GC-MS analysis was performed in SAIF- IIT Madras as per standard
guidelines. GC-MS analysis was performed for KK. GC-MS screening of the drug KK unveiled
the presence of multiple compounds such as Lanosterol, 9,19-cyclolanostan-3-ol,24
methylene-(3β), Tetradecane etc., exhibiting diverse reported biological activities including
potentially beneficial anti-tumor activity against tested carcinoma cells, therefore it deserves
furthermore clinical research in the prospective.
Keywords
Agathiyar vallathi 600, Anti-angiogenesis, Cervical cancer, Kalingathi kadugu.